Anti-TMPO / Thymopoietin

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TMPO antibody recognizes Thymopoietin, a nuclear envelope-associated protein that plays crucial roles in nuclear structure organization, chromatin dynamics, and cell cycle regulation. TMPO exists in multiple isoforms generated by alternative splicing, including LAP2-alpha, LAP2-beta, and LAP2-gamma, which localize to distinct nuclear compartments and perform specialized functions. LAP2-beta and LAP2-gamma are integral components of the inner nuclear membrane that bind Lamin proteins, contributing to nuclear lamina stability, whereas LAP2-alpha remains nucleoplasmic and participates in chromatin assembly and gene regulation. The TMPO gene, located on chromosome 12q22, encodes these isoforms that collectively maintain nuclear architecture and influence genome organization.During cell division, TMPO isoforms coordinate nuclear envelope breakdown and reassembly, interacting with Lamins A/C and chromatin-associated proteins such as BAF (Barrier-to-Autointegration Factor). The interaction between TMPO and Lamin A/C is essential for post-mitotic nuclear reformation and for anchoring chromatin to the nuclear periphery. Dysregulation of TMPO expression or mutation disrupts lamina organization, leading to nuclear morphology defects observed in laminopathies and premature aging syndromes. Beyond its structural roles, TMPO also influences cell proliferation and differentiation by modulating E2F-dependent transcription and histone deacetylase activity.The TMPO antibody is used to detect Thymopoietin and its LAP2 isoforms in various experimental systems, including western blotting, immunofluorescence, and immunohistochemistry. It enables investigation of nuclear envelope integrity, chromatin positioning, and protein-protein interactions involving the nuclear lamina. In disease research, TMPO has been studied for its role in cancer cell cycle regulation and chromatin organization abnormalities. Its involvement in maintaining genomic stability makes it a valuable marker for nuclear envelope dynamics. NSJ Bioreagents offers this antibody optimized for specific recognition of TMPO and LAP2 isoforms, supporting studies in cell biology, aging, and nuclear architecture.