Anti-TLR2 (Toll-Like Receptor 2), clone TLR2/221

Anti-TLR2 (Toll-Like Receptor 2), clone TLR2/221
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2896SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. This mAb reacts with human Toll-like... more
Product information "Anti-TLR2 (Toll-Like Receptor 2), clone TLR2/221"
1 mg/ml in sterile PBS, BSA free, sodium azide free. This mAb reacts with human Toll-like receptor 2 (TLR2). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. Protein function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. [The UniProt Consortium]
Keywords: Anti-TIL4, Anti-TLR2, Anti-CD282, Anti-Toll-like receptor 2, Anti-Toll/interleukin-1 receptor-like protein 4, TLR2 Antibody (Toll-Like Receptor 2)
Supplier: NSJ Bioreagents
Supplier-Nr: V2896SAF-100UG

Properties

Application: FA (activity), FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: TLR2/221
Conjugate: No
Host: Mouse
Reactivity: Human, Monkey, Dog
Immunogen: Recombinant human TLR2 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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