Anti-TLE1 (Synovial Sarcoma Marker), recombinant antibody, clone MSVA-856R

Formulation: Purified Ab with BSA and Azide. Cellular Localization: Nucleus. Positive Control: Tonsil: A weak to moderate TLE1 staining should be seen in suprabasal cells of squamous epithelium and in a small subset of lymphocytes in germinal centres. Chromosome Location: 9q21.32. Protein Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG [The Uniprot Consortium]