Anti-TLE 1 [ZN253] Monoclonal Antibody

TLE 1 Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG [The Uniprot Consortium]