Anti-TL1A

Anti-TL1A Antibody was Ion exchange chromatography purified. A BLAST analysis was used to suggest cross-reactivity with TL1A with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with TL1A from other sources has not been determined. This polyclonal antibody will not react with TL1. TL1A antibody detects human TL1A. Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-kappaB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI). Anti-TL1A antibodies are ideal for investigators involved in apoptosis, NFkappaB, cytokines and growth factors research.