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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
100-401-V86 | 100 µl | - | - |
6 - 10 business days* |
684.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-TIP5 Antibody is monospecific antiserum processed by delipidation and defibrination followed... more
Product information "Anti-TIP5"
Anti-TIP5 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. Cross reactivity with TIP5 from other species not tested. Protein function: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA- binding is required for heterochromatin formation and rDNA silencing. [The UniProt Consortium]
Keywords: | Anti-Tip5, Anti-BAZ2A, Anti-hWALp3, Anti-KIAA0314, Anti-TTF-I-interacting protein 5, Anti-Bromodomain adjacent to zinc finger domain protein 2A, Anti-Transcription termination factor I-interacting protein 5 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 100-401-V86 |
Properties
Application: | ChIP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant protein of human TIP5. |
Format: | Antiserum |
Database Information
KEGG ID : | K15224 | Matching products |
UniProt ID : | Q9UIF9 | Matching products |
Gene ID | GeneID 11176 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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