Anti-TIM50

This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016], Protein function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro, however such activity may not be relevant in vivo. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Mitochondrion inner membrane , Single-pass membrane protein ., [Isoform 2]: Nucleus speckle . Nuclear and enriched in speckles with snRNPs. .