Anti-TIF1 Alpha/TRIM24

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-816A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-816A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Transcriptional coactivator that interacts with numerous nuclear receptors and... more

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Product information "Anti-TIF1 Alpha/TRIM24"

Protein function: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. [The UniProt Consortium]

Keywords:	Anti-RNF82, Anti-TRIM24, Anti-TIF1-alpha, EC=2.3.2.27, Anti-RING finger protein 82, Anti-E3 ubiquitin-protein ligase TRIM24, Anti-Tripartite motif-containing protein 24, Anti-Transcription intermediary factor 1-alpha
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-816A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: bovine, horse, guinea pig, swine, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, naked mole rat, small-eared galago, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A300-816A-T maps to a region between residue 1,000 and the C-terminus (residue 1050) of human Transcriptional Intermediary Factor 1 Alpha using the numbering given in entry NP_056989.2 (GeneID 8805).
Format:	Antigen Affinity Purified