Anti-TIE2 / TEK, clone TEK/9412

1 mg/ml in 1X PBS, BSA free, sodium azide free. Angiopoietin Receptor antibody, also known as TIE2 antibody, recognizes a receptor tyrosine kinase encoded by the TEK gene. This protein is commonly referred to as TIE2, TEK receptor tyrosine kinase, CD202b, and Tunica interna endothelial cell kinase in the literature. TIE2 is a transmembrane receptor primarily expressed in vascular endothelial cells, where it regulates angiogenesis, vascular remodeling, and endothelial cell survival.TIE2 belongs to the receptor tyrosine kinase family and contains extracellular immunoglobulin-like domains, epidermal growth factor-like repeats, fibronectin type III domains, a single transmembrane region, and an intracellular tyrosine kinase domain. Binding of its ligands, Angiopoietin-1 and Angiopoietin-2, induces receptor dimerization and autophosphorylation, leading to activation of downstream pathways including PI3K-AKT and MAPK signaling. These cascades promote endothelial quiescence, vessel maturation, and maintenance of vascular integrity.During embryogenesis, TIE2 signaling is essential for vascular network formation and stabilization. In adult tissues, it maintains endothelial barrier function and regulates vascular permeability. Dysregulated Angiopoietin-TIE2 signaling contributes to tumor angiogenesis, inflammatory disorders, diabetic retinopathy, and vascular malformations. Activating mutations in the TEK gene have been linked to inherited venous malformations, emphasizing the receptor's importance in vascular biology.TIE2 is predominantly localized to the plasma membrane of endothelial cells, with activated receptor complexes undergoing internalization and cytoplasmic signaling. Because of its endothelial-restricted expression profile, Angiopoietin Receptor antibody is widely used in research applications to evaluate vascular structures and angiogenic signaling pathways. An Angiopoietin Receptor antibody can be used to detect TIE2 expression in endothelial biology and tumor angiogenesis research.