Anti-Thyroglobulin(TG), clone YN01586m

Thyroglobulin(TG) is a 330 kDa glycoprotein synthesized by thyroid follicles and expressed in normal thyroid follicular epithelium and glia, thyroid follicular adenoma, thyroid follicular carcinoma and papillary carcinoma. Thyroglobulin(TG) Monoclonal has high tissue specificity and is mainly used in the study of various types of primary and metastatic thyroid follicular epithelial carcinoma. It is a specific marker of normal thyroid tissue and benign and malignant thyroid tumors. Protein function: Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). [The UniProt Consortium]