Anti-THRSP / Thyroid hormone-responsive protein

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. THRSP antibody detects Thyroid hormone-responsive protein, encoded by the THRSP gene on chromosome 11q13.5. THRSP antibody is widely applied in studies of lipid metabolism, endocrine regulation, and cancer biology. THRSP, also known as Spot14, is a nuclear protein induced by thyroid hormone and carbohydrate feeding. It is highly expressed in liver, adipose tissue, and lactating mammary gland, where it regulates lipogenesis by controlling transcription of lipogenic enzymes. In humans, THRSP expression correlates with metabolic state and hormonal regulation, making it a valuable marker for metabolic research.Structurally, THRSP is a ~17 kDa acidic nuclear protein that lacks enzymatic activity but functions as a transcriptional regulator. It contains nuclear localization sequences and DNA-binding domains that interact with chromatin and transcription factors. Its regulation is tightly linked to nutritional and hormonal status, with strong induction by triiodothyronine (T3), glucose, and insulin.Functionally, THRSP promotes lipogenesis by enhancing expression of genes such as fatty acid synthase and acetyl-CoA carboxylase. It plays an important role in lactation, where increased lipogenesis supports milk production. In liver, THRSP regulates triglyceride synthesis and influences lipid storage. Overexpression of THRSP drives lipid accumulation, while deficiency impairs lipid biosynthesis. Researchers use THRSP antibody to investigate lipid metabolism, endocrine signaling, and mammary gland physiology.Clinically, THRSP is associated with metabolic diseases and cancer. Dysregulated THRSP expression contributes to obesity, fatty liver disease, and breast cancer. Elevated expression in breast tumors correlates with lipogenic phenotype and worse prognosis. As a hormone-responsive gene, THRSP also serves as a biomarker of thyroid hormone activity and metabolic adaptation. NSJ Bioreagents provides THRSP antibody for studies in metabolism, endocrinology, and oncology.Experimentally, THRSP antibody is used in western blotting to detect the ~17 kDa protein, in immunohistochemistry to study expression in liver and mammary gland, and in immunofluorescence to analyze nuclear localization. Co-immunoprecipitation with THRSP antibody identifies chromatin-associated complexes involved in lipogenic gene regulation.