Anti-TG / Thyroglobulin, clone TGB/4582R

1 mg/ml in 1X PBS, BSA free, sodium azide free. Thyroid Globulin antibody recognizes Thyroglobulin, a large secreted glycoprotein encoded by the TG gene and produced exclusively by thyroid follicular epithelial cells. Thyroglobulin is the essential precursor for thyroid hormone biosynthesis and is a major structural component of the colloid within thyroid follicles. It provides the scaffold for iodination of tyrosine residues and subsequent coupling reactions that generate thyroxine and triiodothyronine, hormones that regulate metabolism, growth, and systemic energy balance.Thyroglobulin is synthesized in the rough endoplasmic reticulum as a high molecular weight precursor and undergoes extensive folding and glycosylation in the Golgi apparatus before being secreted into the follicular lumen. Within the colloid, specific tyrosine residues are iodinated under the control of thyroid peroxidase. Following stimulation by thyroid stimulating hormone, iodinated Thyroglobulin is endocytosed back into follicular cells and proteolytically processed in lysosomes to release active thyroid hormones into the circulation. This tightly coordinated synthesis and processing pathway underscores the central role of TG in endocrine physiology.Expression of Thyroglobulin is highly restricted to differentiated thyroid tissue under normal conditions. In research settings, Thyroid Globulin antibody is widely used to evaluate thyroid lineage differentiation and follicular cell phenotype. Well differentiated thyroid carcinomas, including papillary and follicular types, typically retain Thyroglobulin expression, whereas poorly differentiated or anaplastic tumors may demonstrate reduced or absent staining. For this reason, TG is an important marker in studies of thyroid tumor progression and differentiation status.Subcellularly, Thyroglobulin localizes to the cytoplasm of thyroid follicular epithelial cells and is abundantly present in the follicular lumen as secreted colloid material. Because of its tissue-specific expression pattern and functional importance in hormone production, Thyroid Globulin antibody is a valuable tool for investigating thyroid development, hormone biosynthesis pathways, and thyroid neoplasia. A Thyroid Globulin antibody can be used in research applications to detect TG protein expression in thyroid tissue models and endocrine disease studies.