Anti-TFPI (Extrinsic pathway inhibitor)

TFPI(Tissue factor pathway inhibitor) also known as EPI, LACI, TFI and TFPT1 is a single-chain , polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, , the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes , significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. The , gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI has a , relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal , region., REFERENCE, UniProt Number: P10646, Gene ID: TFPI, Applications: Suitable for use in Western Blot and Immunohistochemistry (Paraffin). Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.