Anti-TFEB

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG40245.100 100 µl - -

6 - 14 business days*

624.00€
 
Protein function: Transcription factor that specifically recognizes and binds E-box sequences... more
Product information "Anti-TFEB"
Protein function: Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. [The UniProt Consortium]
Keywords: Anti-TFEB, Anti-BHLHE35, Anti-bHLHe35, Anti-Transcription factor EB, Anti-Class E basic helix-loop-helix protein 35
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG40245

Properties

Application: ICC, IF, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant fusion protein corresponding to aa. 1-220 of Human TFEB (NP_009093.1)
MW: 52 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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