Anti-TFB2M

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA028554.25	25 µl		-		3 - 8 business days*		369.00€
ATA-HPA028554.100	100 µl		-		3 - 8 business days*		491.00€

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Protein function: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate... more

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Product information "Anti-TFB2M"

Protein function: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603, PubMed:12068295, PubMed:20410300, PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand (PubMed:29149603, PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 54% and to rat: 54%

Keywords:	Anti-mtTFB2, Anti-hTFB2M, Anti-NS5ATP5, Anti-h-mtTFB, Anti-h-mtTFB2, Anti-HCV NS5A-transactivated protein 5, Anti-Mitochondrial 12S rRNA dimethylase 2, Anti-Mitochondrial transcription factor B2, Anti-Dimethyladenosine transferase 2, mitochondrial
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA028554

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: HLLKHCFGRR SATVIDHLRS LTPLDARDIL MQIGKQEDEK VVNMHPQDFK TLFETIERSK DCAYKWLYDE TLED (ATA-APrEST92122)