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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ABS-KC-1062.50 | 50 µl | - | - |
Request delivery time estimate |
206.00€
|
||
| ABS-KC-1062.100 | 100 µl | - | - |
Request delivery time estimate |
295.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Binds to the mitochondrial light strand promoter and functions in mitochondrial... more
Product information "Anti-TFAM"
Protein function: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:22841477, PubMed:19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). [The UniProt Consortium]
| Keywords: | Anti-Transcription factor A, Anti-mitochondrial, Anti-mtTFA, Anti-Mitochondrial transcription factor 1, Anti-MtTF1, Anti-Transcription factor 6, Anti-TCF-6, Anti-Transcription factor 6-like 2, TFAM Antibody |
| Supplier: | Absea |
| Supplier-Nr: | KC-1062 |
Properties
| Application: | IHC |
| Antibody Type: | Monoclonal |
| Clone: | 13A11 |
| Conjugate: | No |
| Host: | Mouse |
| Species reactivity: | human |
| Immunogen: | Recombinant human TFAM |
| Format: | Solution |
Database Information
| KEGG ID : | K11830 | Matching products |
| UniProt ID : | Q00059 | Matching products |
| Gene ID : | GeneID 7019 | Matching products |
Handling & Safety
| Storage: | -20°C (avoid repeat freezing and thawing cycles) |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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