Anti-TET2

Item number	Size	Manual	Delivery time	Price
A304-247A-T	20 µl (2 blots)	-	3 - 9 business days*	131.00€
A304-247A-M	100 µl (10 blots)	-	3 - 9 business days*	313.00€
A304-247A	100 µl (100 µg)	-	3 - 9 business days*	465.00€

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Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base... more

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Product information "Anti-TET2"

Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. [The UniProt Consortium]

Keywords:	Anti-TET2, Anti-KIAA1546, Anti-Nbla00191, Anti-Methylcytosine dioxygenase TET2
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-247A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Reactivity:	Human (Expected: Chimpanzee, Orangutan)
Immunogen:	synthetic peptide. The epitope recognized by A304-247A-T maps to a region between residue 100 and 150 of human Tet Oncogene Family Member 2 using the numbering given in entry NP_001120680.1 (GeneID 54790).
Format:	Antigen Affinity Purified