Anti-TARDBP / TAR DNA binding protein 43 / TDP43, clone ABAB-20

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. TARDBP encodes TDP-43, a DNA/RNA-binding protein that regulates pre-mRNA splicing, transcript stability, and RNA transport. It shuttles between nucleus and cytoplasm and recognizes UG-rich elements through 2 RNA recognition motifs (RRM1/RRM2), while a low-complexity, glycine-rich C-terminus supports protein-protein and ribonucleoprotein assembly. Through these activities, TDP-43 coordinates RNA processing programs that influence neuronal function and broader cell biology.TDP-43 participates in stress-responsive ribonucleoprotein remodeling and interacts with components of transcription, splicing, and translation pathways. Changes in localization, solubility, or post-translational status are widely monitored as readouts in studies of RNA metabolism, proteostasis, and cellular stress adaptation across model systems.The TARDBP antibody enables specific detection of endogenous TDP-43 in applications such as western blot, immunofluorescence, immunohistochemistry, and immunoprecipitation. Researchers use the TARDBP antibody from NSJ Bioreagents to quantify total protein, assess nuclear-cytoplasmic distribution, and evaluate biochemical fractionation outputs. With high specificity and consistent performance, the TARDBP antibody supports rigorous analysis of RNA-binding protein networks and RNA processing dynamics.