Anti-TAOK1 / TAO kinase 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TAOK1 antibody detects TAO kinase 1, a serine/threonine-protein kinase involved in stress signaling, cytoskeletal dynamics, and neuronal development. The UniProt recommended name is Serine/threonine-protein kinase TAO1 (TAOK1), also known as MAP3K16 or thousand and one amino acid kinase 1. This kinase functions upstream of mitogen-activated protein kinase (MAPK) cascades, including the p38 and JNK pathways, which regulate apoptosis, microtubule stability, and cellular stress responses.Functionally, TAOK1 antibody identifies a 100 kDa enzyme that phosphorylates and activates MAP2Ks such as MKK3 and MKK6, leading to downstream activation of p38 MAPK. TAOK1 also modulates the cytoskeleton by interacting with microtubule-associated proteins, including MARK kinases. This regulation is critical for neuronal polarity, axon specification, and dendrite formation. During mitosis, TAOK1 contributes to spindle orientation and chromosome alignment, linking stress signaling with cell-cycle progression.The TAOK1 gene is located on chromosome 17q11.2 and encodes a multi-domain kinase composed of an N-terminal catalytic domain and a C-terminal regulatory region. It functions as both a signaling hub and structural organizer by localizing to centrosomes, Golgi membranes, and the cytoplasmic microtubule network. Autophosphorylation and stress-induced activation enhance TAOK1 activity, enabling rapid response to environmental and mechanical stimuli.TAOK1 has gained prominence for its role in neurodevelopment. Mutations or dysregulation of TAOK1 are associated with neurodevelopmental disorders, including autism spectrum disorder and intellectual disability. Experimental evidence shows that TAOK1 depletion impairs axonal growth, disrupts neuronal morphology, and alters synaptic signaling. In non-neuronal cells, TAOK1 mediates apoptotic signaling through activation of p38 and JNK under oxidative or osmotic stress conditions.TAOK1 antibody is a versatile reagent for analyzing kinase signaling, cytoskeletal organization, and stress-induced apoptosis. It is commonly used in immunoblotting, immunofluorescence, and kinase activity assays to evaluate TAOK1 expression and activation. In cancer research, TAOK1 contributes to epithelial-to-mesenchymal transition (EMT) and metastasis, while in neurons, it supports differentiation and network connectivity. NSJ Bioreagents offers TAOK1 antibody reagents validated for research applications in signal transduction, neurobiology, and cellular stress regulation.