Anti-Tankyrase 1

Anti-Tankyrase 1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-399A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-399A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-399A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling... more
Product information "Anti-Tankyrase 1"
Protein function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. [The UniProt Consortium]
Keywords: Anti-TNKS, Anti-ARTD5, Anti-TANK1, Anti-TNKS-1, Anti-PARP5A, EC=2.4.2.30, Anti-Tankyrase-1, Anti-Tankyrase I, Anti-Poly [ADP-ribose] polymerase 5A, Anti-ADP-ribosyltransferase diphtheria toxin-like 5
Supplier: Bethyl Laboratories
Supplier-Nr: A302-399A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A302-399A-T maps to a region between residue 1277 and 1327 of human TRF1-interacting ankyrin-related ADP-ribose polymerase using the numbering given in entry NP_003738.2 (GeneID 8658).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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