Anti-TAK1

Anti-TAK1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-916A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-916A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-916A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase... more
Product information "Anti-TAK1"
Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2- induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. [The UniProt Consortium]
Keywords: Anti-TAK1, Anti-MAP3K7, Anti-TGF-beta-activated kinase 1, Anti-Mitogen-activated protein kinase kinase kinase 7, Anti-Transforming growth factor-beta-activated kinase 1
Supplier: Bethyl Laboratories
Supplier-Nr: A301-916A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A301-916A-T maps to a region between residue 450 and 500 of human transforming growth factor-beta-activated kinase 1 using the numbering given in entry NP_663304.1 (GeneID 6885).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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