Anti-TAF6 / TATA-box binding protein-associated factor 6

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TAF6 antibody detects TATA-box binding protein-associated factor 6, a core subunit of the transcription factor IID (TFIID) complex that plays a central role in the initiation of RNA polymerase II-dependent transcription. The UniProt recommended name is Transcription initiation factor TFIID subunit 6 (TAF6). This protein is one of several TBP-associated factors (TAFs) that assemble with the TATA-binding protein (TBP) to recognize and bind core promoter regions, facilitating recruitment of the transcriptional machinery and gene activation.TAF6 is an integral structural and functional component of TFIID, contributing to promoter recognition, nucleosome remodeling, and transcription start site selection. The TFIID complex serves as a scaffold for preinitiation complex formation, interacting with transcriptional regulators, general transcription factors, and coactivators. TAF6 participates in DNA binding and mediates protein-protein interactions with other TAF subunits, including TAF9 and TAF12, forming submodules that stabilize TFIID assembly and promoter binding.The TAF6 antibody identifies a protein of approximately 68 kDa encoded by the TAF6 gene on chromosome 7q22.3. Multiple isoforms of TAF6 are generated through alternative splicing, including the pro-apoptotic TAF6? variant, which lacks a short exon and promotes programmed cell death independently of p53 signaling. The balance between canonical TAF6 and TAF6? isoforms influences cellular responses to stress and apoptosis, highlighting the protein's dual role in both transcriptional regulation and cell survival pathways.Functionally, TAF6 contributes to basal and regulated transcription by integrating signals from transcriptional activators and chromatin modifiers. It participates in the regulation of genes involved in cell cycle progression, DNA repair, and differentiation. TAF6 dysfunction or altered expression has been associated with impaired gene regulation and has been investigated in the context of cancer and neurodegenerative disorders, where transcriptional control is disrupted.TAF6 antibody is useful for applications such as immunoblotting, immunohistochemistry, and immunofluorescence to study transcription complex composition, promoter occupancy, and RNA polymerase II recruitment. It enables detection of TAF6 in nuclear extracts, cultured cells, and tissue samples, supporting research into transcriptional regulation and stress-induced gene expression. NSJ Bioreagents provides TAF6 antibody reagents optimized for studies of transcription initiation, chromatin interaction, and gene expression control.