Anti-TAB2

Anti-TAB2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ5767 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Mitogen-activated protein kinase kinase... more
Product information "Anti-TAB2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, also known as TAB2, is an enzyme that in humans is encoded by the MAP3K7IP2 gene. The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2 functionally links TAK1 to TRAF6. What's more, TAB2 can act as a sensor for inflammatory signals by serving as a molecular beacon for recruitment of MEKK1(MAP3K1), which in turn mediated dismissal of the NCOR/HDAC complex and permitted derepression of AR and estrogen receptor target genes. Protein function: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. [The UniProt Consortium]
Keywords: Anti-TAB2, Anti-TAB-2, Anti-KIAA0733, Anti-TAK1-binding protein 2, Anti-TGF-beta-activated kinase 1-binding protein 2, Anti-TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, TAB2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: RQ5767

Properties

Application: WB, IHC (paraffin), FC, Direct ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant human protein (amino acids Q169-K522)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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