Anti-SYNJ2BP / Synaptojanin-2-binding protein

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SYNJ2BP antibody detects Synaptojanin-2-binding protein, a mitochondrial outer membrane protein that regulates protein targeting, mitochondrial morphology, and endoplasmic reticulum-mitochondria contact. SYNJ2BP acts as an adaptor linking the mitochondrial surface to signaling and trafficking proteins, influencing energy metabolism and cellular stress responses. The SYNJ2BP antibody is widely used in mitochondrial biology and cell signaling research to study organelle communication, trafficking, and apoptosis regulation.SYNJ2BP is encoded by the SYNJ2BP gene on human chromosome 14q22.1. The protein is approximately 118 amino acids in length and contains a PDZ-binding motif that mediates interactions with synaptojanin-2 and other cytoplasmic adaptors. It localizes to the outer mitochondrial membrane, where it plays a role in tethering mitochondria to the endoplasmic reticulum and modulating calcium and lipid exchange between the two organelles.The SYNJ2BP antibody detects a 13 kilodalton band by western blot and exhibits mitochondrial and perinuclear staining patterns under confocal microscopy. SYNJ2BP interacts with the PDZ domain of SYNJ2, which links phosphoinositide metabolism to mitochondrial signaling. By maintaining proper mitochondrial-endoplasmic reticulum contact sites, SYNJ2BP supports cellular homeostasis and regulates apoptotic sensitivity under metabolic stress.Functionally, SYNJ2BP contributes to the stabilization of mRNAs on the mitochondrial surface and may assist in local translation of mitochondrial proteins. Loss of SYNJ2BP disrupts organelle coupling and leads to mitochondrial fragmentation, altered calcium signaling, and reduced energy efficiency. In cancer and metabolic disorders, SYNJ2BP expression correlates with altered mitochondrial dynamics and oxidative phosphorylation capacity.Beyond its role in organelle tethering, SYNJ2BP participates in endothelial cell migration and angiogenesis by coordinating signal transduction from cell surface receptors to mitochondria. This function connects metabolic status with cell motility and vascular remodeling. Because of its position at the interface of metabolism, trafficking, and signaling, SYNJ2BP is a valuable model for studying mitochondrial communication and adaptation to stress.NSJ Bioreagents provides a validated SYNJ2BP antibody optimized for its applications, enabling precise investigation of mitochondrial contact sites, signaling pathways, and metabolic regulation.