Anti-SWT1 / C1orf26

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The SWT1 antibody targets Pre-mRNA-splicing factor SWT1 homolog, a nuclear protein encoded by the SWT1 gene. This enzyme is involved in RNA processing, quality control, and surveillance pathways that ensure proper pre-mRNA splicing and ribonucleoprotein maturation. Pre-mRNA-splicing factor SWT1 homolog is an RNA endonuclease that trims aberrant or misprocessed RNA precursors, maintaining transcriptome fidelity. The SWT1 antibody provides researchers with a reliable tool for studying nuclear RNA metabolism, splicing complex dynamics, and gene expression regulation.Pre-mRNA-splicing factor SWT1 homolog localizes to nucleoplasmic and nucleolar regions where active splicing occurs. It contains conserved zinc-finger and endonuclease domains required for RNA substrate recognition and cleavage. The SWT1 antibody allows visualization of this nuclear factor, enabling the investigation of its roles in processing small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs). Through these actions, SWT1 contributes to ribosome biogenesis and overall RNA quality assurance within the nucleus.Loss or dysfunction of Pre-mRNA-splicing factor SWT1 homolog leads to accumulation of defective pre-mRNA and abnormal spliceosome assembly, disrupting normal gene expression. The SWT1 antibody aids in identifying changes in SWT1 expression or localization in experimental systems subjected to transcriptional stress or RNA splicing inhibition. Studies indicate that this factor participates in safeguarding the transcriptome against RNA processing defects that can trigger cellular stress responses.Beyond RNA metabolism, SWT1 may interact with other nuclear RNA decay enzymes, coordinating pathways that remove splicing intermediates and cryptic transcripts. The SWT1 antibody supports mechanistic studies exploring these complexes, helping define how nuclear RNA degradation interfaces with splicing surveillance. Its conservation from yeast to humans highlights an evolutionarily stable role in RNA integrity maintenance.The SWT1 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, showing strong nuclear staining consistent with RNA processing activity. NSJ Bioreagents provides this antibody with validated specificity for RNA biology and molecular genetics research. By enabling accurate detection of Pre-mRNA-splicing factor SWT1 homolog, the SWT1 antibody supports exploration of RNA quality control mechanisms, nuclear surveillance pathways, and the molecular links between RNA metabolism and gene expression stability.