Anti-SV2A / Synaptic vesicle glycoprotein 2A, clone r15E11

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. SV2 Protein antibody recognizes Synaptic vesicle protein 2A, commonly referred to as SV2A, a multi-pass transmembrane protein encoded by the SV2A gene that localizes to synaptic vesicle membranes within presynaptic nerve terminals. SV2 Protein Antibody is developed to detect endogenous Synaptic vesicle protein in research applications focused on neuronal communication and vesicle trafficking. SV2A is widely expressed throughout the central nervous system in both excitatory and inhibitory neurons, where it contributes to regulated neurotransmitter release and synaptic vesicle cycling.Synaptic vesicle protein 2A is a member of the SV2 family, which includes SV2A, SV2B, and SV2C. The protein spans the vesicle membrane multiple times and is enriched in presynaptic terminals, where it modulates vesicle priming, exocytosis efficiency, and calcium-dependent neurotransmitter release. Although its precise molecular mechanism remains under investigation, SV2A is recognized as a critical regulator of synaptic strength and vesicular release probability.The SV2A gene is located on chromosome 1q21.3 and is highly enriched in brain regions with dense synaptic connectivity, including cortex, hippocampus, and cerebellum. In addition to neuronal tissues, Synaptic vesicle protein 2A is detected at lower levels in certain endocrine and neuroendocrine cells, consistent with its broader role in regulated secretory pathways. Altered SV2A expression has been associated with epilepsy and other neurologic disorders. Notably, Synaptic vesicle protein 2A serves as the molecular binding target of the antiepileptic drug levetiracetam, highlighting its translational importance in seizure research.Because SV2A is consistently present in presynaptic terminals, it is widely used as a marker of synaptic density and neuronal integrity in studies of neurodevelopment, neurodegeneration, and brain injury. Changes in Synaptic vesicle protein levels may reflect synaptic remodeling or loss in experimental models.Clone r15E11 is a recombinant mouse monoclonal antibody that recognizes Synaptic vesicle protein 2A and supports studies of synaptic vesicle biology, neurotransmitter release mechanisms, and neuronal network organization.