Anti-SV2A Rabbit (Clone RM520)

Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane glycoprotein and member of the keratan sulfate proteoglycan family. It is composed of N- and C-terminal cytosolic domains and 12 transmembrane domains interspersed with two ATP-binding regions, a cytoplasmic loop, and an extracellular loop. SV2A also contains multiple glycosylation and phosphorylation sites. It is ubiquitously expressed in the brain, with brain region-dependent expression in glutamatergic or GABAergic neurons, and localizes to the presynaptic membrane. It is also expressed in the peripheral nervous system in sympathetic synapses, slow motoneurons, and platelets, as well as in the pancreas. SV2A interacts with synaptotagmin-1 (Syt1), a protein involved in calcium-dependent synaptic vesicle fusion, and is involved in trafficking Syt1 during synaptic vesicle endocytosis. Glycosylated SV2 proteins, including SV2A, act as receptors for C. botulinum neurotoxin type A1. Biallelic loss-of-function mutations in SV2A are associated with epileptic encephalopathy, a disorder characterized by early-onset epilepsy, microcephaly, and neurodevelopmental delay. Cayman's SV2A Rabbit Monoclonal Antibody (Clone RM520) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.. Cross reactivity: (+) SV2A: .. Protein function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. [The UniProt Consortium]