Anti-SUV39H1

Anti-SUV39H1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-127A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-127A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-127A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3... more
Product information "Anti-SUV39H1"
Protein function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. [The UniProt Consortium]
Keywords: Anti-KMT1A, Anti-SUV39H1, EC=2.1.1.43, Anti-H3-K9-HMTase 1, Anti-Su(var)3-9 homolog 1, Anti-Lysine N-methyltransferase 1A, Anti-Histone H3-K9 methyltransferase 1, Anti-Position-effect variegation 3-9 homolog, Anti-Suppressor of variegation 3-9 homolog 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-127A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-127A-T maps to a region between residue 25 and 75 of human suppressor of variegation 3-9 homolog 1 using the numbering given in entry NP_003164.1 (GeneID 6839).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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