Anti-Superoxide dismutase [Mn], mitochondrial (SOD2)

SOD2(Superoxide Dismutase 2), also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that , scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport , reactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide , dismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, , they demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH , analysis, indicated that SOD2 is in the distal portion of 6q25. The SOD2 gene encodes an , intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide , produced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the , human SOD2 gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion , cells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic , nerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease , process. UniProt Number: P04179, Gene ID: SOD2, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.