Anti-SUMO1, clone SUMO1/1188

Anti-SUMO1, clone SUMO1/1188
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2919IHC-7ML 7 ml - -

3 - 10 business days

541.00€
 
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. This... more
Product information "Anti-SUMO1, clone SUMO1/1188"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. This mAb is specific to SUMO-1 and shows no cross-reaction with either SUMO-2 or SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane. Protein function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1, this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). [The UniProt Consortium]
Keywords: Anti-GMP1, Anti-SMT3C, Anti-Smt3C, Anti-SUMO1, Anti-SUMO-1, Anti-Sentrin, Anti-SMT3 homolog 3, Anti-GAP-modifying protein 1, Anti-Ubiquitin-like protein UBL1, Anti-Ubiquitin-like protein SMT3C, Anti-Small ubiquitin-related modifier 1, SUMO1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2919IHC-7ML

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SUMO1/1188
Conjugate: No
Host: Mouse
Reactivity: Human, Rat (Expected: Broad)
Immunogen: Recombinant human SUMO1 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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