Anti-SULT1C2 / Sulfotransferase 1C2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SULT1C2 antibody detects Sulfotransferase 1C2, a cytosolic enzyme that catalyzes the sulfation of hormones, xenobiotics, and small phenolic compounds, facilitating their metabolism and excretion. Encoded by the SULT1C2 gene on chromosome 2q12.3, this protein belongs to the sulfotransferase 1C family within the larger SULT superfamily of phase II metabolic enzymes. SULT1C2 uses the sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to transfer sulfate groups to hydroxyl or amine substrates, increasing their solubility and promoting detoxification.SULT1C2 is expressed mainly in fetal liver, kidney, and gastrointestinal tissues, with lower levels in adult organs. It plays an important role in the developmental regulation of xenobiotic metabolism. In the liver, SULT1C2 helps conjugate thyroid hormones, estrogens, and xenobiotic phenols, contributing to endocrine balance and protection from toxic compounds. Variations in SULT1C2 expression or activity influence drug metabolism, hormone clearance, and chemical susceptibility, making it relevant to pharmacogenetics and toxicology studies.The SULT1C2 antibody is used to study enzymatic detoxification, hormone metabolism, and tissue-specific sulfation patterns. Western blot analysis identifies a 34 kilodalton band corresponding to SULT1C2, and immunohistochemistry reveals cytoplasmic localization in hepatocytes and renal tubular cells. This antibody supports research into the biochemical pathways of sulfate conjugation and developmental regulation of phase II metabolism. Because sulfotransferases influence drug bioavailability and toxicity, the SULT1C2 antibody is a valuable reagent for pharmacological and toxicological investigations.Beyond metabolism, SULT1C2 may participate in cell signaling and differentiation by modulating the availability of bioactive molecules. Altered expression has been observed in cancers of the colon, liver, and lung, suggesting roles in tumor metabolism and chemical carcinogen processing. NSJ Bioreagents provides the SULT1C2 antibody validated for its applications, ensuring specificity in studies of metabolic enzyme regulation and drug response variability.