Anti-STP1

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880, PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008], Protein function: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. [The UniProt Consortium] Recommended dilutions: IHC-p 1:50-200. Cellular localization: Nucleus . Chromosome . Loaded onto the nucleosomes of condensing spermatids. .