Anti-STOML3 / Stomatin-like protein 3

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. STOML3 antibody detects Stomatin-like protein 3, a membrane-associated modulator of mechanosensation and ion channel activity. Encoded by the STOML3 gene on chromosome 13q14.2, this protein belongs to the stomatin family, which includes membrane-bound scaffolding proteins involved in sensory transduction and membrane organization. STOML3 contains a conserved stomatin-like domain that mediates protein-lipid and protein-protein interactions, particularly with mechanosensitive ion channels such as PIEZO2 and ASICs. It localizes to vesicular and plasma membranes in sensory neurons, where it regulates mechanotransduction sensitivity.STOML3 plays a crucial role in peripheral mechanosensation by enhancing the responsiveness of mechanosensitive ion channels to mechanical stimuli. It forms oligomeric complexes that influence channel gating and localization within mechanosensory end-organs. In dorsal root ganglion neurons, STOML3 interacts with PIEZO2 to amplify mechanosensitive currents required for touch and proprioception. Genetic deletion of STOML3 in mice leads to significant deficits in mechanical sensitivity without affecting nociception, demonstrating its specificity for tactile function.The STOML3 antibody is widely used in neurobiology and sensory physiology research to detect Stomatin-like protein 3 and study its interactions with mechanosensory ion channels. Western blot analysis identifies a 32 kilodalton band corresponding to STOML3, while immunofluorescence shows punctate cytoplasmic staining in sensory neurons and mechanosensory tissues. The antibody allows visualization of STOML3 localization within neuronal projections and sensory end-organs, supporting investigations into the molecular basis of touch sensation.Beyond sensory neurons, STOML3 expression has been reported in lung and kidney tissues, suggesting broader roles in mechanotransduction and membrane curvature regulation. It may also participate in lipid raft organization and vesicular trafficking. The STOML3 antibody enables researchers to explore these processes and provides a key reagent for examining the molecular architecture of mechanosensitive signaling complexes. NSJ Bioreagents provides this antibody validated for its applications, ensuring high specificity and reproducibility in sensory and mechanotransduction studies.