Anti-STK33 / Serine/threonine-protein kinase 33

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The STK33 antibody targets Serine/threonine-protein kinase 33, a cytoplasmic kinase encoded by the STK33 gene. Serine/threonine-protein kinase 33 phosphorylates cytoskeletal and signaling proteins to regulate apoptosis, spermatogenesis, and metabolic processes. Although its precise substrates remain under investigation, STK33 is involved in kinase cascades that control cell survival and stress adaptation. The STK33 antibody enables researchers to explore kinase signaling, protein phosphorylation, and pathways relevant to oncogenesis and germ-cell differentiation.Serine/threonine-protein kinase 33 belongs to the calcium/calmodulin-dependent kinase superfamily and contains a conserved catalytic domain typical of serine/threonine kinases. It localizes mainly in the cytoplasm but may associate with actin filaments and mitochondria under stress conditions. The STK33 antibody allows localization analysis to assess how cellular context affects its distribution and activity. In germ cells, STK33 plays a role in sperm flagellum assembly and maturation, supporting reproductive function.Aberrant activation of Serine/threonine-protein kinase 33 has been associated with tumor progression in various cancers, including leukemia, glioma, and pancreatic carcinoma. The STK33 antibody supports research into these roles by enabling detection of protein levels in tumor tissues and evaluating the impact of genetic silencing or kinase inhibition. Some studies have suggested STK33 as a synthetic lethal partner with KRAS mutations, linking it to targeted cancer therapy exploration.Beyond oncology, Serine/threonine-protein kinase 33 contributes to cytoskeletal organization and stress responses. It may phosphorylate structural proteins that stabilize actin networks and maintain cellular morphology. The STK33 antibody enables analysis of these cytoskeletal effects and supports biochemical assays aimed at identifying STK33 substrates and binding partners. Its expression has also been noted in cardiac and skeletal muscle, indicating a potential role in contractile function.The STK33 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, displaying cytoplasmic staining consistent with its kinase activity. NSJ Bioreagents provides this antibody as a validated reagent for use in molecular biology, oncology, and developmental studies. By supporting detailed analysis of Serine/threonine-protein kinase 33, the STK33 antibody advances understanding of kinase signaling, cytoskeletal regulation, and disease mechanisms related to cellular stress and proliferation.