Anti-STIM2 / Stromal interaction molecule 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. STIM2 antibody detects Stromal interaction molecule 2, a calcium sensor encoded by the STIM2 gene located on chromosome 4p15.2. STIM2 is an endoplasmic reticulum (ER) transmembrane protein that regulates store-operated calcium entry (SOCE) by sensing ER luminal calcium levels and activating plasma membrane Orai calcium channels. It belongs to the STIM family along with STIM1 but plays a more subtle role in maintaining basal calcium levels and preventing cytosolic calcium depletion. STIM2 is expressed widely, with high levels in brain, skeletal muscle, and immune cells, where calcium signaling is crucial for cellular function.Structurally, STIM2 consists of an N-terminal luminal EF-hand domain that binds calcium, a sterile alpha motif (SAM) that senses ER calcium depletion, a single transmembrane region, and a cytoplasmic coiled-coil domain that interacts with Orai and TRPC channels. It belongs to the stromal interaction molecule family of calcium sensors. Co-localization studies show STIM2 distributed in the ER membrane, clustering near plasma membrane regions during calcium signaling activation.Functionally, STIM2 modulates calcium entry by maintaining the readiness of Orai1 channels for activation. It operates at lower calcium threshold levels than STIM1, allowing fine-tuned regulation of basal calcium homeostasis. In neurons, STIM2 regulates synaptic activity and plasticity by modulating calcium-dependent gene transcription. In T lymphocytes, it supports sustained calcium signaling required for cytokine production. Known interaction partners include Orai1, TRPC1, and STIM1, forming calcium entry complexes at ER-plasma membrane junctions.STIM2 plays a critical role in various physiological processes including muscle contraction, neuronal signaling, and immune cell activation. Dysregulation of STIM2 has been linked to neurodegenerative diseases, immunodeficiency, and cardiac hypertrophy. Reduced STIM2 expression impairs calcium-dependent transcription, while overexpression disrupts calcium oscillations. Pathway associations include calcium signaling, ER stress response, and MAPK pathway activation. During development, STIM2 expression supports neuronal differentiation and synaptic maturation.The STIM2 antibody from NSJ Bioreagents is a valuable reagent for research into calcium signaling, ER function, and neuronal activity regulation.