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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V8105-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V8105-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Signal transducer and activator of... more
Product information "Anti-STAT5b, clone STAT5B/2657"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation. Protein function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. [The UniProt Consortium]
Keywords: | Anti-STAT5B, Anti-Signal transducer and activator of transcription 5B, STAT5b Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V8105 |
Properties
Application: | ELISA |
Antibody Type: | Monoclonal |
Clone: | STAT5B/2657 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant full-length human STAT5B protein |
Format: | Purified |
Database Information
KEGG ID : | K11224 | Matching products |
UniProt ID : | P51692 | Matching products |
Gene ID | GeneID 6777 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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