Anti-STAT3

Anti-STAT3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-405A-T 10 µl (10 µg) -

6 - 10 business days*

131.00€
A302-405A 100 µl (100 µg) -

6 - 10 business days*

465.00€
 
Protein function: Signal transducer and transcription activator that mediates cellular responses... more
Product information "Anti-STAT3"
Protein function: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. [The UniProt Consortium]
Keywords: Anti-Acute-phase response factor, Anti-Signal transducer and activator of transcription 3
Supplier: Bethyl Laboratories
Supplier-Nr: A302-405A

Properties

Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat, Bovine, Pig)
Immunogen: synthetic peptide. The epitope recognized by A302-405A-T maps to a region between residue 675 and 725 of human signal transducer and activator of transcription 3 using the numbering given in entry NP_644805.1 (GeneID 6774).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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