Anti-STAT2 / Signal transducer and activator of transcription 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. STAT2 antibody detects Signal transducer and activator of transcription 2, a transcription factor central to interferon (IFN) signaling and antiviral defense. Encoded by the STAT2 gene on chromosome 12q13.2, this protein is a member of the STAT family of latent cytoplasmic transcription factors that transmit signals from cytokine receptors to the nucleus. STAT2 is activated by phosphorylation in response to type I interferons (IFN-alpha and IFN-beta), forming part of the ISGF3 (interferon-stimulated gene factor 3) transcriptional complex with STAT1 and IRF9 to regulate antiviral gene expression.Upon cytokine stimulation, STAT2 undergoes phosphorylation on tyrosine 690 by Janus kinases (JAK1 and TYK2), dimerizes with STAT1, and associates with IRF9. This trimeric complex translocates to the nucleus, where it binds interferon-stimulated response elements (ISREs) in the promoters of interferon-stimulated genes (ISGs), initiating transcription of antiviral effectors such as OAS1, MX1, and ISG15. These gene products suppress viral replication and enhance immune defense mechanisms.The STAT2 antibody is widely used in immunology, virology, and cell signaling research to examine interferon pathways, innate immune activation, and transcriptional regulation. Western blot analysis detects a 113 kilodalton band corresponding to STAT2, while immunofluorescence reveals both cytoplasmic and nuclear staining following interferon treatment. This antibody enables detailed analysis of IFN-mediated signal transduction and transcriptional regulation in various immune and epithelial cell types.STAT2 plays a critical role not only in antiviral immunity but also in inflammation, cancer immunosurveillance, and immune tolerance. Deficiency or mutation of STAT2 causes severe susceptibility to viral infections due to impaired interferon signaling, while persistent activation of the JAK-STAT pathway is associated with tumor progression and chronic inflammation. The STAT2 antibody supports exploration of these processes and evaluation of therapeutic modulation of interferon pathways. NSJ Bioreagents validates this antibody for its applications, ensuring accurate and reproducible detection in immune signaling studies.