Anti-STAM2 / Signal transducing adaptor molecule 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. STAM2 antibody detects Signal transducing adaptor molecule 2, a component of the endosomal sorting complex required for transport (ESCRT-0) that regulates receptor-mediated endocytosis and signal downregulation. The UniProt recommended name is Signal transducing adaptor molecule 2 (STAM2). This adaptor protein cooperates with HGS to recognize ubiquitinated cargo and recruit downstream ESCRT machinery for lysosomal degradation.Functionally, STAM2 antibody identifies a 512-amino-acid cytosolic protein containing VHS, SH3, and ubiquitin-interacting motifs. STAM2 binds to HGS, clathrin, and ubiquitinated receptors, guiding cargo sorting into multivesicular bodies. By directing receptor trafficking, STAM2 attenuates signaling from growth factor receptors, cytokine receptors, and immune complexes.The STAM2 gene is located on chromosome 2p13.1 and is expressed ubiquitously, with high abundance in immune and epithelial cells. STAM2 functions downstream of activated receptors such as EGFR, ensuring signal termination through endosomal sorting. Its interaction with tyrosine kinases and deubiquitinating enzymes provides regulatory balance between receptor activation and degradation.Pathologically, disrupted STAM2 expression or mutation can impair receptor turnover, leading to prolonged signaling and oncogenic transformation. Overactivation of endocytic pathways involving STAM2 has been implicated in cancer and immune dysregulation. Research using STAM2 antibody helps elucidate receptor trafficking, ubiquitin signaling, and endosomal dynamics.STAM2 antibody is suitable for western blotting, immunoprecipitation, and immunofluorescence to detect ESCRT-0 complex components and study receptor endocytosis. NSJ Bioreagents supplies STAM2 antibody reagents validated for membrane trafficking, ubiquitin signaling, and receptor regulation research.Structurally, STAM2 contains an N-terminal VHS domain for cargo recognition, a central SH3 domain mediating protein interactions, and C-terminal ubiquitin-binding motifs. This configuration allows STAM2 to integrate receptor internalization with signaling termination. This antibody supports investigations into vesicular trafficking and cell signaling regulation.