Protein function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. [The UniProt Consortium]
synthetic peptide. The epitope recognized by A303-293A-T maps to a region between residue 400 and 450 of human Signal Transducing Adaptor Molecule (SH3 domain and ITAM motif) 1 using the numbering given in entry NP_003464.1 (GeneID 8027).