Anti-ST2V (Suppressor of Tumorigenicity 2, ST2, ST2L, DER4, FIT-1, Homolog of Mouse Growth Stimulati

ST2V is a 259aa membrane protein belonging to the interleukin 1 receptor family with two transmembrane helices, one TIR domain and three Ig-like C2-type (immunoglobulin-like) domains. ST2V is a novel variant of human ST2 which has isoforms ST2L, ST2S, ST2V and ST2LV. It is usually expressed in the human leukemic cell line UT-7 and it's sublines UT-7:GM, UT-7:EPO, and UT-7:TPO, in addition to human helper T cell line 5C10. Reports suggest that it is possibly involved in helper T-cell function. ST2V can be induced by proinflammatory stimuli and is a receptor for interleukin-33 (IL-33). IL-33 binds to and signals through ST2V and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3:ERK1 and/or MAPK1:ERK2, MAPK14, and MAPK8. The possible roles of ST2V in growth and differentiation are intriguing. It is predominantly expressed in stomach, small intestine and colon. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 3-5ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Daudi and NIH 3T3 cell lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.