Anti-SSH3 / Slingshot homolog 3

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SSH3 antibody detects Slingshot homolog 3, a member of the slingshot family of serine/threonine phosphatases that regulate actin filament dynamics through dephosphorylation of cofilin. The UniProt recommended name is Slingshot homolog 3 (SSH3). This phosphatase modulates cytoskeletal reorganization, cell migration, and synaptic remodeling by maintaining the balance between phosphorylated and active cofilin.Functionally, SSH3 antibody identifies a 575-amino-acid cytoplasmic enzyme that acts downstream of Rho family GTPases. SSH3 dephosphorylates cofilin at serine 3, restoring its actin-severing activity and promoting filament turnover. The protein also interacts with scaffolding components such as 14-3-3 proteins and LIM kinases, coordinating actin remodeling in response to extracellular cues.The SSH3 gene is located on chromosome 3p21.31 and is widely expressed in brain, muscle, and epithelial tissues. SSH3 contributes to cell shape changes, migration, and polarity through dynamic actin regulation. In neurons, it participates in synaptic plasticity and axon guidance by fine-tuning cytoskeletal rearrangements during development and signaling.Pathologically, aberrant SSH3 activity disrupts cytoskeletal organization and has been associated with cancer metastasis and neurological disorders. Overactivation enhances cell motility and invasion, whereas loss of function impairs normal morphogenesis. Research with SSH3 antibody supports studies on actin regulation, neuronal development, and signal transduction.SSH3 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry, enabling precise detection of SSH3 in various cell types. NSJ Bioreagents provides SSH3 antibody reagents validated for actin cytoskeleton and phosphatase signaling research.Structurally, SSH3 contains an N-terminal catalytic domain related to the dual-specificity phosphatase family and C-terminal regions mediating protein-protein interactions. Its localization and activity are regulated by phosphorylation and 14-3-3 binding. This antibody facilitates analysis of SSH3's role in actin filament turnover and cell motility control.