Anti-SSH3

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1, MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo.SSH3 (Slingshot Protein Phosphatase 3) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Cytoskeletal Signaling. GO annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1. Protein function: Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. [The UniProt Consortium]