Anti-SSA1

Anti-SSA1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-519A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-519A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-519A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1,... more
Product information "Anti-SSA1"
Protein function: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139). [The UniProt Consortium]
Keywords: Anti-SS-A, Anti-RNF81, Anti-TRIM21, Anti-Ro(SS-A), EC=6.3.2.-, Anti-52 kDa Ro protein, Anti-RING finger protein 81, Anti-Sjoegren syndrome type A antigen, Anti-E3 ubiquitin-protein ligase TRIM21, Anti-Tripartite motif-containing protein 21
Supplier: Bethyl Laboratories
Supplier-Nr: A302-519A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-519A-T maps to a region between residue 425 and 475 of human Sjogren syndrome antigen A1 using the numbering given in entry NP_003132.2 (GeneID 6737).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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