Anti-SRPK2

Anti-SRPK2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-467A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-467A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-467A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates... more
Product information "Anti-SRPK2"
Protein function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. [The UniProt Consortium]
Keywords: EC=2.7.11.1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-467A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Little Brown Bat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-467A-T maps to a region between residue 425 and 475 of human SFRS protein kinase 2 using the numbering given in entry NP_872633.1 (GeneID 6733).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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