Anti-SPTLC1 (Long chain base biosynthesis protein 1)

SPTLC1(Serine palmitoyltransferase, long chain base subunit 1), also known as SPT1, LCB1, is a , protein which in humans is encoded by the SPTLC1 gene. Dawkins et al. (2001)noted that the SPTLC1 , gene maps to chromosome 9q22.1-q22.3. Serine palmitoyltransferase, which consists of two different , subunits, is the initial enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl CoA to , 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain , base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with , hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have , been identified. UniProt Number: O15269, Gene ID: SPTLC1, Applications: Suitable for use in Western Blot and Immunohistochemistry (Paraffin). Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.