Anti-Spred1

Anti-Spred1 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with Spred1 with Human, Rat and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Spred1 from other sources has not been determined. This Spred1 antibody is predicated to have no cross reactivity to Spred2 and Spred 3. Spred1 antibody detects human Spred1. The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes. it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). Anti-Spred1 antibodies are ideal for investigators involved in cell cycle proteins and cancer research.