Anti-SPOCK1 / Testican 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SPOCK1 antibody detects Testican-1, a secreted glycoprotein that modulates extracellular matrix organization, protease activity, and cell migration. The UniProt recommended name is Testican-1 (SPOCK1). This protein belongs to the SPARC/osteonectin family and contributes to tissue remodeling, neural development, and tumor invasion through regulation of extracellular proteolytic balance.Functionally, SPOCK1 antibody identifies a 438-amino-acid protein characterized by domains for proteoglycan attachment and calcium binding. SPOCK1 inhibits metalloproteinases such as MMP2 and cathepsin L, thereby influencing extracellular matrix turnover. It also interacts with glycosaminoglycans and cell surface receptors to regulate adhesion, proliferation, and differentiation. In the nervous system, SPOCK1 supports axon guidance, synaptic stability, and neurogenesis. In non-neural tissues, it contributes to angiogenesis and wound repair.The SPOCK1 gene is located on chromosome 5q31.2 and is expressed in brain, kidney, heart, and various epithelial tissues. Expression is regulated during embryogenesis and tissue regeneration and is modulated by growth factors including TGFbeta and EGF. SPOCK1's matrix-associated properties make it a key component in maintaining extracellular homeostasis.Pathologically, elevated SPOCK1 expression has been linked to tumor progression and metastasis in cancers such as lung, liver, and prostate carcinoma. By modulating MMP activity and promoting epithelial-mesenchymal transition (EMT), SPOCK1 enhances invasion and angiogenesis. Conversely, in neural tissues, dysregulation affects axonal pathfinding and synapse formation. Research using SPOCK1 antibody supports studies in cancer metastasis, extracellular matrix biology, and neural development.SPOCK1 antibody can be validated for western blotting, immunohistochemistry, and ELISA to detect extracellular matrix proteins. NSJ Bioreagents provides SPOCK1 antibody reagents optimized for research in tumor microenvironment, neural growth, and protease regulation.Structurally, Testican-1 contains an N-terminal proteoglycan domain with glycosaminoglycan attachment sites, followed by Kazal-type protease inhibitor and calcium-binding domains. Its modular organization allows inhibition of proteolytic enzymes and stabilization of extracellular matrix components. This antibody enables analysis of SPOCK1's function in matrix remodeling, neural morphogenesis, and tumor biology.