Anti-SPINDLY/CCDC99

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-354A-T	10 µl (2 µg)		-		2 - 8 business days*		165.00€
A301-354A	100 µl		-		2 - 8 business days*		586.00€

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Protein function: Required for the localization of dynein and dynactin to the mitotic kintochore.... more

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Product information "Anti-SPINDLY/CCDC99"

Protein function: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). [The UniProt Consortium]

Keywords:	Anti-hSpindly, Anti-Protein Spindly, Anti-Arsenite-related gene 1 protein, Anti-Rhabdomyosarcoma antigen MU-RMS-40.4A, Anti-Coiled-coil domain-containing protein 99, Anti-Spindle apparatus coiled-coil domain-containing protein 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-354A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: chimpanzee, crab-eating macaque)
Immunogen:	synthetic peptide. The epitope recognized by A301-354A-T maps to a region between residue 475 and 525 of human SPINDLY (coiled-coil domain containing 99) using the numbering given in entry NP_060255.2 (GeneID 54908).
Format:	Antigen Affinity Purified