Anti-SPECC1L / Cytospin A

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SPECC1L antibody targets sperm antigen with calponin homology and coiled-coil domains 1-like protein, an important cytoskeletal-associated molecule involved in embryonic development, craniofacial morphogenesis, and cellular architecture. Encoded by the SPECC1L gene located on chromosome 22q11.23, this protein plays a role in actin cytoskeleton dynamics and intercellular adhesion. Through its calponin homology and coiled-coil domains, SPECC1L interacts with microtubules and actin filaments, contributing to structural integrity and tissue organization during embryogenesis.Mutations in the SPECC1L gene have been linked to developmental syndromes such as Opitz G/BBB syndrome, Teebi hypertelorism syndrome, and other craniofacial malformation disorders. These mutations often result in abnormal craniofacial patterning, defects in palate formation, and midline developmental anomalies. In particular, studies have shown that SPECC1L dysfunction disrupts cell adhesion and epithelial sheet movement, processes essential for palate shelf elevation and fusion. Understanding SPECC1L function is therefore critical to developmental biology and congenital anomaly research.Research involving SPECC1L has also uncovered its involvement in neural crest cell migration and craniofacial morphogenesis, with significant implications for both basic and clinical research. Experimental data suggest that SPECC1L contributes to cranial neural crest cell adhesion and migration by stabilizing cytoskeletal structures. Loss of SPECC1L function results in altered actin filament organization and impaired cell polarity, leading to tissue-level defects. These observations make SPECC1L antibody an important tool for assessing protein expression in tissues during key developmental stages and for disease-modeling studies.SPECC1L is expressed in a variety of tissues, with higher levels during embryonic stages. Antibodies against this protein have been employed in immunohistochemistry to detect craniofacial developmental anomalies in experimental models and in western blotting to validate expression levels across different tissues. The antibody enables researchers to track protein localization within cells, providing insights into cytoskeletal remodeling and signaling networks. Because SPECC1L's activity intersects with multiple cytoskeletal regulators, it is of high interest for broader investigations into tissue morphogenesis and human genetic disorders.